Hepatotoxicity: What You Need to Know About Drug-Induced Liver Damage

When your liver gets hurt by a medication or supplement, that’s called hepatotoxicity, damage to the liver caused by drugs, chemicals, or supplements. Also known as drug-induced liver injury, it’s not rare — and it can sneak up on you even if you’re taking something you’ve used for years. The liver is your body’s main filter, so it’s always working to break down what you swallow. But sometimes, that process backfires. Instead of safely clearing the substance, it turns into a toxin that attacks liver cells.

This isn’t just about illegal drugs or overdoses. Even common pills like acetaminophen, the active ingredient in many pain relievers and cold meds can cause serious harm if taken too long or too much. Other culprits include antibiotics, anti-seizure drugs like carbamazepine, used for epilepsy and bipolar disorder, and even some herbal supplements. People often assume "natural" means safe, but that’s not true — some herbs are just as hard on the liver as prescription drugs. And here’s the catch: you might not feel anything until the damage is already done. Fatigue, nausea, yellow eyes, dark urine — these are late signs. Early on, it’s usually silent.

That’s why doctors check liver enzymes during routine blood tests, especially if you’re on long-term meds. Some people are more at risk — older adults, those with existing liver conditions, or anyone taking multiple drugs at once. It’s not just about the drug itself, but how your body handles it. Your genes, your diet, your alcohol use — all of it plays a role. That’s why one person can take a drug for years with no issues, while another gets liver damage after just a few weeks.

What you’ll find in the posts below are real-world stories and clear comparisons about drugs that can harm your liver — from HIV meds like Biktarvy to antidepressants like Clofranil, and even common pain relievers. You’ll learn which ones carry the highest risk, how to spot trouble early, and what to ask your doctor before starting or switching anything. No guesswork. No fluff. Just what matters for your liver and your health.