Duphaston: What It Is, How It Works, and What You Need to Know

When your body doesn’t make enough Duphaston, a synthetic form of the hormone progesterone used to regulate menstrual cycles and support early pregnancy. Also known as dydrogesterone, it’s not a birth control pill—it’s a targeted hormone therapy that helps balance what your body is missing. Many women turn to Duphaston after being told their progesterone levels are low, especially if they’re trying to conceive or dealing with irregular periods. Unlike natural progesterone, Duphaston is designed to mimic its effects without the side effects of other hormone treatments.

It’s commonly prescribed for progesterone therapy, a treatment used to support the lining of the uterus during the second half of the menstrual cycle, which is critical for implantation and early pregnancy. If your body doesn’t produce enough progesterone after ovulation, the uterine lining can break down too soon, leading to missed periods or early miscarriage. Duphaston steps in to stabilize that lining, giving a fertilized egg a better chance to attach. It’s also used for menstrual disorders, conditions like amenorrhea, oligomenorrhea, or premenstrual syndrome caused by hormonal imbalance, and for managing symptoms of endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus, causing pain and infertility.

People often wonder how Duphaston compares to other progesterone options like natural supplements or injections. It’s taken orally, so it’s easier than shots, and it doesn’t cause the drowsiness or mood swings some women get with other progestins. But it’s not for everyone—women with liver disease, undiagnosed vaginal bleeding, or a history of certain cancers should avoid it. Your doctor will check your hormone levels and medical history before prescribing it.

What you’ll find in the posts below are real-world insights from people who’ve used Duphaston—or similar treatments—to manage fertility, regulate cycles, or cope with hormone-related pain. You’ll see comparisons with other drugs, stories about side effects, and practical advice on timing, dosage, and what to expect when you start. Whether you’re just starting out or have been on it for months, this collection gives you the unfiltered facts you won’t get from a pharmacy leaflet.