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Opioids and Adrenal Insufficiency: A Rare but Life-Threatening Side Effect You Need to Know
31 December 2025 Casper MacIntyre

Opioids and Adrenal Insufficiency: A Rare but Life-Threatening Side Effect You Need to Know

Opioid-induced adrenal insufficiency is a rare but life-threatening side effect of long-term opioid use. It suppresses cortisol production, leading to fatigue, dizziness, and risk of adrenal crisis during illness. Early testing and steroid support can reverse it.

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