Tag: HPA axis suppression

Opioids and Adrenal Insufficiency: A Rare but Life-Threatening Side Effect You Need to Know

Opioid-induced adrenal insufficiency is a rare but life-threatening side effect of long-term opioid use. It suppresses cortisol production, leading to fatigue, dizziness, and risk of adrenal crisis during illness. Early testing and steroid support can reverse it.